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9598 Mechanistically, in the absence of impaired kidney function, more than 95% of TMAO in the human body is excreted through renal tubules or glomerular filtration, 99,100 suggesting a potential mechanism for elevated circulating TMAO levels when renal function is impaired

doi:10.1016/j.jacl.2024.03.001 Hackler E, 3rd, Lew J, Gore MO, et al

Strikingly, the level of synthesis of FAHFA isomers is highly correlated to insulin sensitivity with their synthesis being dramatically reduced in adipose tissue of humans exhibiting insulin resistance

doi: 10.2174/18715222113139990008, 12

Weight regain is common during treatment interruptions