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The appropriate choice of the chemical form of vitamin B 12 , the dose, and treatment time will depend on individual factors such as the type of vitamin B 12 deficiency, age, preexisting diseases, type of methylation gene, and medication used

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May 5 2017;6(5)doi:10.1161/JAHA.116.004896 Rotter I, Kosik-Bogacka D, Dolegowska B, Safranow K, Karakiewicz B, Laszczynska M

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5-amino-1MQ, an analogue from our initial series of NNMT inhibitors with low IC 50 value (IC 50 = ~1 M;[17]), and high cell membrane permeability (Table 2), produced the greatest reduction of intracellular 1-MNA levels at a concentration of 10 M among tested inhibitors (Figure 2D)