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Beyond serving as a risk factor, T2DM has been shown to worsen disease progression and increase symptom severity in PD [65]
Merkuri F, Rothstein M, Simoes-Costa M
Many research efforts have been conducted to delay the introduction of levodopa in patients, which has eventually led to the development of dopamine agonists as monotherapy, with a theory stating that the administration of dopamine agonists can delay the development of motor complications if administered before levodopa [20]
Further, several defensive signalling pathways like MAP kinase, Ca 2+ , ROS, ABA etc
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