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Research consistently shows lower GPx in affected patients compared to healthy individuals, highlighting its protective shortfall

These metabolites can be broadly classified into water-soluble antioxidantssuch as proline, glycine betaine, ascorbic acid (AsA), and glutathione (GSH)and lipophilic antioxidants, including tocopherols and carotenoids, reflecting both their chemical properties and intracellular compartmentalization (Mishra et al

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Furthermore, in a study of NA supplementation with a dose of 207.5 mg NA per day for 32 days to older adults with impaired physical function, no improvements in NAD + or mitochondrial functions in skeletal muscle were observed 321