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Several non-pharmaceutical therapies are commonly used to support this process, including: Acupuncture , which modulates dopamine pathways, reduces sensory hyperexcitability, and calms spinal reflex loops involved in involuntary movement Electroacupuncture or gentle neuromodulation , which provides consistent input to stabilize erratic nerve signaling in moderate to severe cases Manual therapy and therapeutic massage , which activate mechanoreceptors that compete with abnormal sensory signals and reduce nighttime urgency Targeted relaxation and breathing therapies , which shift the nervous system out of a heightened alert state and improve sleep onset Sleep-focused nervous system retraining , which helps restore proper downshifting at night through timing, sensory reduction, and autonomic balance These therapies work synergistically by lowering overall nervous system noise, making it easier for the brain to suppress unnecessary movement signals during rest

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Treatment In cases where a person has slept with their arm underneath their body, the symptoms are temporary and will go away after removing the pressure

Energy production Mitochondria use NAD+ to shuttle electrons through the electron transport chain

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