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Men with such markers may benefit from peptides that support mitochondrial function or DNA repair, for example, MOTS-c analogs or peptides that upregulate antioxidant pathways

Beginners should start with 200-250 mcg daily, split into two doses of 100-125 mcg each, administered 12 hours apart via subcutaneous injection

The two papers that originally established this mechanism have been retracted

Pickart estimated lethal dose at approximately 22,500 mg for humans (300-fold above effective doses), with animal LD50 studies in mice showing 8 mg per 25g mouse (320 mg/kg, translating to ~22,400 mg for 154 lb human)

Published 2019 Dec 9