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This oxidative milieu persists even after glucose normalization, contributing to the phenomenon of metabolic memory observed in clinical trials, where early intensive glycemic control provides long-term protection against complications (Yang et al., 2024)

which results in misfolded protein accumulation, neuronal demyelination and axon damage

Investigators focus on determining the maximum tolerated dose , identifying dose-limiting toxicities, and observing the drug's pharmacokinetics (absorption, distribution, metabolism, and excretion)

10.3390/antiox11020408 15 AsimM.AwanR.Ur RashidH.HussainF

The following sections will discuss up-to-date findings on the metabolic biomarkers of key disturbed metabolic pathways in keratinocytes and T cell subpopulations (Table 1)