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Lapatinib induces mitochondrial dysfunction to enhance oxidative stress and ferroptosis in doxorubicin-induced cardiomyocytes via inhibition of PI3K/AKT signaling pathway

Failure to degrade damaged mitochondria in a timely manner triggers a vicious cycle of sustained PANoptosis activation

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The cell culture was grown in tissue-culture treated Corning flasks (Sigma-Aldrich) in a humidified atmosphere (5% CO 2 ) at 37 C (HeraCell 150C incubator, Heraeus, Hanau, Germany)

Tesofensine's key efficacy data comes from a 2008 Phase 2 trial published in The Lancet involving 203 obese adults randomised to 0.25mg, 0.5mg, or 1.0mg daily tesofensine for 24 weeks