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N Engl J Med 329(12):850854 Verebey K, Alrazi J, Jaffe JH (1988) The complications of ecstasy (MDMA)

This activation triggers a cascade of effects that reduce appetite and slow the movement of food through the digestive system

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The loading phase builds tissue concentration over 4 to 6 weeks, after which maintenance dosing preserves benefits with reduced frequency
