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Degenerative disc sequencing on adult human tissue also identified ECM regulatory networks and observed that ECM related genes were associated with multiple growth factors (Riester et al., 2018)

During the tendon repair, the experimental groups were injected around the Achilles tendon with 350mmol/L (low dose group) and 1000mmol/L (high dose group) D-ribose 0.2 ml respectively to increase the AGEs level, while in the control group were given the same amount of PBS
