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Risks of B12 Deficiency in Pregnancy Vitamin B12 levels tend to drop during pregnancy, which may increase the risk of a B12 deficiency

Medically reviewed by Janice Litza, MD This article was medically reviewed by Janice Litza, MD

Yet the consequences are unknown Bioavailability: there are four specific metabolic steps necessary to convert cyanocobalamin into one of the coenzyme forms, which is a clear metabolic disadvantage (3) Utilisation problems: certain hereditary diseases, as well as metabolic disorders, prevent the conversion of cyanocoalamin into the active B12 forms (4) Steals methyl groups: cyanocobalamin requires a methyl group to convert into methylcobalamin, which it takes from the important amino acid S-adenosylmethionine (SAM)

Vitamin B12 is an essential nutrient to humans

This can lead to missed diagnoses or inadvertent over prescribing of medicines