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Clinical signs of Thiamine deficiency include fatigue, muscle weakness, loss of appetite and increased heart rate
Am J Emerg Med 27: 1176.e13

Experimental studies report activation of signaling mechanisms related to vascular remodeling, including Notch-associated pathways and endothelial cell activation in angiogenesis models [8]

doi: 10.1186/1532-429X-10-42

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