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doi: 10.1016/j.crgsc.2021.100176 168 MukhopadhyayRKaziJDebnathMC

It is a component of two essential cofactors used by numerous cellular enzymes, including methylenetetrahydrofolate reductase (MTHFR), a critical enzyme in folate and homocysteine metabolism

Some people do say there are adverse events

Components Chemically, the difference between L arginine and arginine AKG is that while L-arginine is composed of an optical isomer of arginine, rotating the plane-polarized light anticlockwise, arginine AKG is composed of the salt of l-arginine and alpha-ketoglutarate

"So you have a wide variety of people promoting these medications, anywhere from personal trainers all the way up to physicians," Varney said