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98 In fact, macrophages are heterogeneous and derive from different ontological origins during liver damage: resident yolk sac-derived macrophages, also known as Kupffer cells (KCs), and circulating bone marrow MoMFs

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Most of the senescent cells have flattened cell morphology, promiscuous gene expression, a proinflammatory secretory response, and positive SA- -gal staining at pH 6.0 [18]

IGF-2 Similarly to IGF-1, concentration of IGF-2 also markedly decreases in patients with liver cirrhosis, as compared to healthy individuals