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At the ultrastructural level, irregular and immature elastin fibers and fibers devoid of microfibrils were observed. These findings suggested that both elastic fiber abnormalities and reduced collagen content contribute to the clinical features seen in patients with clEDS. There were no consistent electron microscopy (EM) findings in the ten patients in our cohort who had EM performed

PLOS ONE 12 , e0183228 (2017)

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Higher inflammatory state is believed to be involved in the development and maintenance of hypertension [3], but many of the mechanisms that start and then maintain this elevated inflammatory state are yet to be determined