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Other reactions, such as exchanges of atoms of [H + N] (e.g., amination), [H + N O] (e.g., hydrolysis of amide), [2H + C] (e.g., methylation), [2H + O] (e.g., hydration) and [2H] (e.g., reduction), were also among the top-ranked unknown reactions (Fig

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These results highlight that targeting pathways involved in -KG production offers attractive therapeutically opportunities in diseases associated with macrophage malfunction