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This elevation was accompanied by myospasm of the surrounding muscles when pouting or pursing the lips (Figure 2)

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Further experience with the use of anti-CD38 antibodies in RRMM after prior treatment with daratumumab will stem from a current phase Ib trial of SC isatuximab in combination with Pd (NCT04045795) and for daratumumab from a phase II study in combination with Kd (NCT03871829)

While mechanistically interesting, stacking three or more compounds dramatically increases complexity, cost, and potential for unexpected interactions

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