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For example, overexpression of the BRCP/ABCG2 transporter is associated with resistance to several anti-cancer drugs including doxorubicin, mitoxantrone and topotecan [65], whilst ABCB1/MDR1 is frequently overexpressed in drug-resistant cell lines and is found to correlate with poor overall survival in patients [20, 66]

Y., Lin J

Okuda, H

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Therefore, future research should include more human-based clinical trials that account for individual physiological and disease-related variations, tailoring dietary interventions and treatment strategies to the specific microbiome and metabolic responses of each patient