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With these bioactive forms, the B12 does not need to be converted by your genes/enzymes in order to be available for use by your cells (conversion can be a problem for people with MTR, MTRR, COMT as well as other gene defects)

Maybe some autoimmune issue where immune system attacked nerves, or inflammation

I use the micronutrient panels from Vibrant Wellness because the panels show intracellular and extracellular nutritional status

A lack of B6 in your system usually shows up as: Skin problems (Seborrheic dermatitis) - an oily, flaky rash might appear on your face, neck or chest

However, over-supplementation may cause headaches, anxiety, or sleep disturbances in sensitive individuals