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Current AD treatments target pathological changes but often fail to noticeably slow disease progression and can cause severe complications, limiting their effectiveness

Kojic Acid: Known for its skin-lightening properties , Kojic acid diminishes sun damage, scars, and age spots

These conditions appear during the developmental period and ultimately lead to disabilities that may impair a person not only physically but also intellectually throughout the individuals lifetime [1] ( see Figure 2 )

Sirius red staining with polarized microscopy was conducted to evaluate the maturity of the extracellular matrix, especially secretion and production of collagen type 1, which is the major component in tendon and scarring tissue