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Oxidants also promote SKN-1 nuclear localization via the p38 mitogen-activated protein kinase (MAPK) pathway 18,56

Cytokine storms due to uncontrolled activation of the innate immune system, release of DAMPs during tissue injury, and intravascular thrombosis have all been associated with the function and malfunction of neutrophils (Fig

Beyond direct cytotoxic effects, OS plays a pivotal role in initiating immune activation in vitiligo

doi: 10.4110/in.2012.12.5.189

These side effects usually develop secondary to the peripheral antimuscarinic effects of these modalities, and evidence has shown that some events might be severe and lead to the discontinuation of a study
