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Systemic oxidative or reductive stress as well as inflammation -as seen in aging and being affected by xCT deletion- can have profound effects on brain metabolism [42, 43]

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Despite the individual variability, a specific cognitive profile of subjects with DS is reported in the literature: communication skills are generally found to pose the most significant challenges, non-verbal reasoning is a relative strength 22 , daily living skills are somewhat stronger, and socialization is the strongest adaptive skill 23,24,25

An overview of the mechanisms by which oxidative distress contributes to pathological conditions is also presented, along with a discussion of the emerging therapeutic potentials of natural and synthetic supersulfides in treating oxidative stress-related diseases

Depress Anxiety 27 , 11111116 (2010)