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The suppression of the type I IFN response by ROS is due to oxidation of cysteine 147 of murine stimulator of IFN, an ER membrane protein that mediates the IFN response after cytoplasmic DNA sensing 59,133,134

19 (2025): e2422446122

Filippakopoulos P, Qi J, Picaud S, Shen Y, Smith W, Fedorov O, et al

They are also typically stronger, more numerous, and associated with smaller, evenly distributed fat lobules factors that minimize skin irregularities even with higher adiposity
