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LCACs have also been suggested to have dose-dependent inhibitory effects on cardiac K + currents, including the transient outward K + current ( I to ) (Xu and Rozanski, 1998) and ATP-sensitive K + current ( I K,ATP ) (Haruna et al., 2000), which translate to a prolongation of the APD

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TML undergoes a series of enzymatic reactions, including -N-trimethyl-lysine hydroxylase (HTMLA), -butyryl transferase (BBOX), etc., and is finally converted into L-carnitine
