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Global Spine J., 8:776-783, 2019 PMID: 30560028 Tarazona DA, Schroeder GD, Vaccaro A.R., Radcliff KE

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found that neutrophils infiltration into brain tissue due to BBB rupture caused an increased production of MPO, accompanied by lipid oxidative damage in the hippocampus and prefrontal cortex, suggesting a vicious circle between BBB destruction and MPO production (Margotti et al., 2020)