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The frequency and duration of the protocol reflect this sustained systemic signaling requirement
Patients report sustained improvements in energy, body composition, recovery, cognitive function, and overall vitality

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Notably, creatine uptake via the creatine transporter (SLC6A8) supports cellular resilience during immune activation by sustaining metabolic capacity in macrophages and T cells, with SLC6A8-dependent creatine transport influencing cytokine responses, effector function, and immune cell homeostasis processes that may limit excessive inflammatory damage under conditions of sustained activation (43, 45, 46)

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