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Stromal fibrin further shapes the immune infiltration landscape by acting as both a physical barrier and biochemical niche that restricts CD8 + T cell and tumor-associated macrophage penetration from the tumor stroma into the tumor parenchyma (171)

Usage Cited in: Transl Oncol

Cuprizone-brain damage and motoric disability The used cuprizone regimen, several times higher than those regularly used in cuprizone studies (62), rapidly induced marked functional disability along with severely affected various brain areas

( g ) Cells were treated with the IDH1 inhibitor alone and supplemented with propionylcarnitine (Prop-Carn) or butyrylcarnitine (But-Carn) (n = 3 technical replicates representative from 2 independent experiments in each cell line)

Additionally, PQ downregulates SLC7A11 and GPX4 expression and upregulates cyclooxygenase-2 expression, thereby promoting oxidative stress and ferroptotic cell death ( 4.2 Genetic models 4.2.1 SNCA models Overexpression of wild-type or mutant (A53T, A30P) -syn induces Lewy body-like inclusions in dopaminergic neurons, leading to significant neuron damage and degeneration