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Valproate-induced hyperammonaemic encephalopathy In chronic VPA dosing hyperammonaemia occurs in nearly 50% of patients, but this remains asymptomatic in almost 50% of cases [39]

Acknowledgements This study was supported by Suzhou Municipal Key Core Technology Research Projects (2023SS19) and Youth Excellence Projects of CNNC (CNNC-2020)

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The combination of vancomycin, neomycin sulfate, metronidazole, ampicillin, and other broad-spectrum antibiotics can alleviate choline-induced atherosclerosis in mice, and the mechanism may be related to the inhibition of choline conversion to TMA, the reduction of TMAO levels, and the inhibition of macrophage foaming