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NRF2 is subsequently stabilized to transcriptionally upregulate antioxidant response genes including xCT, the rate-limiting enzyme in glutathione synthesis, glutamate cysteine ligase (GCL), and enzymes used in detoxification of ROS, such as GPx [42], to attenuate ROS damage
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Illustratively, in rats with duodenocolic fistulas, leaking, failure of biomechanical, functional, diarrhea, weight loss, and a long-standing perilous course with cachexia were all counteracted

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