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and (5) positive serology confirmed by immunocytochemistry, Western blot, ELISA, or radioimmunoassay

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However, its application is limited by the unpredictability of graft survival

In hereditary hemochromatosis, downregulation of the cystine-glutamate transporter directly exacerbates ferroptosis-driven liver injury, while N-acetylcysteine supplementation restores glutathione levels and inhibits ferroptotic cell death [54]