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Yet another compound, Honokiol (HKL), has been shown to protect against doxorubicin-induced cardiotoxicity by activating SIRT3, which helps reduce ROS production, prevent mitochondrial fragmentation, and promote mitochondrial fusion 187

It is worth noting that the derivation of HBGVs applies extrapolation factors (also termed safety factors) to account for toxicodynamic and toxicokinetic differences between species and inter-individual variability in humans

[DOI] [PubMed] [Google Scholar] 86.Bhattacharyya B., Chatterjee T.K., Ghosh J.J