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When B12 enters the digestive system, it is initially bound to proteins in food

Control mice were treated with the same amount of DMSO after diluted in PBS

1953, Washington, D.C: Government Printing Office, 133-134

for example, the greatest fold changes for alanine were observed among the most sensitive cells to MTX, whereas 2-oxoglutarate (-ketoglutarate) greatest fold changes were found among the most resistant cells to the antifolate ( Figure 1C )
