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Mechanical damage caused by elevated IOP leads to altered axoplasmic flow in RGCs, while reduced blood flow and perfusion pressure at the posterior pole also contribute to neuronal damage

The examples CMS cites in its noticesuch as non-medical in-home services, internet access for rural healthcare providers, and workforce development initiativesoften represent state-led innovations designed to address local community needs efficiently, especially in rural and underserved areas where healthcare resources are already strained

doi: 10.1146/annurev.biochem.71.110601.135414

All SAEs will be followed up until satisfactory resolution or until the treating physicians and the principal investigator deem the event to be chronic or the participant to be stable