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Description
In states of obesity and metabolic dysfunction, NNMT is often overexpressed in adipose tissue, depleting nicotinamide and reducing NAD+ availability [2]

Meanwhile, the body temperature of mice from different groups did not vary significantly from each other, and weekly food consumption displays a large fluctuation between groups, but the trend is consistent between groups (Figures 3C,D)

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A result significantly different indicates a wrong compound or major synthesis error

Pfenninger, E
