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According to the paper, which was published in Science Translational Medicine, one of the clear-skinned participants ending up developing acne one week after recieving the vitamin B12 injection

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The association between nicotinamide N-methyltransferase gene polymorphisms and primary hypertension in Chinese Han Population

Some patients report a mild headache or a feeling of lightheadedness after an IM injection

25 Folate Duration of therapy Patients with pernicious anemia require lifelong therapy, while patients with malabsorption require treatment until underlying condition or diet is corrected