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Sudar-MilovanovicEObradovicMJovanovicAZaricBZafirovicSPanicAet al

However, it can also be linked to underlying inflammation, poor biomechanics, or systemic factors that reduce tissue recovery

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Although various studies on copper-induced cell death have shown promising results, there still remain several challenges, such as how the aggregation of fatty acylated proteins triggers cell death, optimizing the performance of copper regulators and reducing their side effects, determining the mode of death induced by copper overload and deficiency, gaining a comprehensive understanding of the roles of copper in the mitochondria, and whether copper ion carriers can selectively deliver drugs to hypertrophic myocardial tissues through drug delivery systems (183)

The economic calculation favours strict adherence to the 28-day limit wasted reagent is far cheaper than wasted time and animal models