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Protein thiol oxidation reactions, in particular S-glutathionylation, have also been found to play a crucial role in modulating mitochondrial physiology, structure, and bioenergetics (Hurd et al., 2005

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Brequinar, an inhibitor of dihydroorotate dehydrogenase (DHODH) in the de novo pyrimidine biosynthesis pathway, was found to suppress tumor growth in xenograft models of SCLC (56)

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doi: 10.1021/acssynbio.4c00589 84 XiaJZhangLZhuWTuJPengXDengQet al

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