melanotic macule inner cheek Smokers melanosis . Oral pigmentation seen in heavy smokers . Investigations have shown ability of melanin to bind to noxious substances. . Exposure to polycyclic amines ( Nicotine & benzpyrene) has shown Simple cryosurgical treatment of the
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[PubMed] [Google Scholar] 8.Chen Z.-Y., Zhang Y

Sources: Spana C, et al
doi: 10.1113/jphysiol.2013.251629

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