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Ca 2+ mishandling leads to Ca 2+ overaccumulation, which in mitochondria causes the opening of the mPTP and initiation of cell death, thereby affecting cellular energy supply and insulin signaling

10.1038/s41467-023-38148-7 [DOI] [PMC free article] [PubMed] [Google Scholar] 26.Slieker RC, Donnelly LA, Fitipaldi H et al (2021) Replication and cross-validation of type 2 diabetes subtypes based on clinical variables: an IMI-RHAPSODY study

Nasal, pulmonary, and transdermal delivery systems are among the approaches being investigated
[DOI] [PubMed] [Google Scholar] 89.Nieman DC, Laupheimer MW, Ranchordas MK, Burke LM, Stear SJ, Castell LM

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