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Description
PreissHandler and de novo do not occur within the mitochondria, based on the nuclear or cytosolic localization of QPRT, NAPRT, and NADS 48

Environ Toxicol Chem, 17 : 99108

All four Rspondins are either predominantly expressed in the DP with substantially lower levels in the matrix ( Rspo1 , Rspo2 , and Rspo4

Coloso RM, Stipanuk MH

A nasal spray is also available but is not considered the best treatment for severe deficiency because B12 is not absorbed as well as it is via injection
