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Ledipasvir and Sofosbuvir for Untreated HCV Genotype 1 Infection Published May 15, 2014 N Engl J Med 2014;370:1889-1898 DOI: 10.1056/NEJMoa1402454 Abstract Background In phase 2 studies, treatment with the all-oral combination of the nucleotide polymerase inhibitor sofosbuvir and the NS5A inhibitor ledipasvir resulted in high rates of sustained virologic response among previously untreated patients with hepatitis C virus (HCV) genotype 1 infection

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The interaction between lipid peroxidation and apoptosis primarily occurs in mitochondrial, where critical signaling pathways converge to regulate cell death