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GHB WITHDRAWAL SYNDROME Clinical Presentation The acute pharmacological effects of GHB and GBL are of relatively short duration because of the rapid clearance of parent drug from the bloodstream and also the lack of any active metabolites

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Darkness, low light or shade mostly reduced GST activity, while high light significantly elevated the activity and expression of GSTs and also GSH levels

A thorough evaluation can help determine whether sleep disturbances might be related to the medication or if other factors such as obstructive sleep apnea, stress, caffeine intake, or other medications might be contributing