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Cisplatin exposure directly induces follicle loss, while metformin treatment encourages the resumption of follicular growth and development in the ovaries, showing that primordial follicles and growing follicles are largely restored and atretic follicles are significantly reduced in cisplatin-treated ovaries

However, the exact mechanisms by which homocysteine influences epigenetic modifications and the specific genes affected are areas of ongoing investigation

Ramassamy C, Averill D, Beffert U, Theroux L, Lussier-Cacan S, Cohn JS, Christen Y, Schoofs A, Davignon J, and Poirier J

MET also enhances the anti-TB immune response of macrophages, including ROS production, phagosome maturation, and phagocytosis

Intravenous contrast It is commonly used for computed tomography scanning, intravenous urography and angiography
