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5 Piezo1 as a potential therapeutic target for CNS diseases As previously described, the overactivation of Piezo1 is highly correlated with the onset and progression of many CNS disorders

Protein deglycase DJ-1, functions as a redox sensor with peroxiredoxin-like activity protecting neurons against oxidative stress [153,154]

[38,39] Geroprotective effect of Metformin has been reported in multiple animal models including lifespan extension in Caenorhabditis elegans , Drosophila melanogaster and mice, and deceleration of aging clocks in male nonhuman primates

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