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W przypadku zagadnien dermatologicznych udokumentowanych jest kilka ograniczen fizykochemicznych
The safety of hydroquinone: a dermatologist's response to the 2006 Federal Register

doi: 10.1016/j.mvr.2024.104684 138

Their multiple thiol-binding sites have increased affinity for metals and render PCs more efficient in chelating several metal ions [36,52]

Once a dog has begun taking a vitamin B12 supplement, small improvements may be seen in just a few days, but it can take several weeks before the dog fully responds to treatment.