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Description
Nrf2 is an important component of the cellular defense against various exogenous and endogenous stresses that can be activated in response to a series of oxidative and electrophilic stimulations (Kensler et al., 2007)

Chen S, Fan J, Xie P, Ahn J, Fernandez M, Billingham LK, et al

Reference: Alpert A J, Gilbert H F

These microglia release various pro-inflammatory factors, which further disrupt iron balance, creating a detrimental feedback loop

Together, these factors determine whether necroptotic signaling leads to effective antitumor immunity or chronic inflammation that supports tumor progression (20, 48, 49)
