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doi: 10.3389/fendo.2025.1529231 Received 13 February 2025 Accepted 20 June 2025 Published 07 July 2025 Volume 16 - 2025 Edited by Ramith Ramu, JSS Academy of Higher Education and Research, India Reviewed by Marija Stojanovic, University of Belgrade, Serbia Weizhuo Tang, Changsha University, China Updates Copyright 2025 Chang, Shi, Wang, Lu, Guan and Wu

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As well as providing an overview of the components that regulate glutathione homeostasis (synthesis, degradation, transport, and redox turnover), the present discussion considers the roles of this metabolite in physiological processes such as light signaling, cell death, and defense against microbial pathogen and herbivores

26,27 Notably, IFN-, a crucial pro-inflammatory cytokine, appears to have a dual role in regulating HSC proliferation

Accumulated uraemic toxins and gut microbiome changes in CKD contribute to neurological damage, cellular ageing and cognitive decline