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These observations inform current models of how eIF2-P activates a long-range conformational change through the eIF2B core to regulate eIF2B GEF activity

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Metabolic outcomes of ABHD11 inhibition in CD8 + T cells Metabolism is markedly different between immortalized cancer cells and primary cells, and while the major effect of ABHD11 inhibition in HeLa cells was on 2-OG metabolism and 2-OGDD activity, the downstream consequences of perturbing this glutaryllipoyl pathway in primary cells may differ from immortalized cancer cells

Luo, and by the National Natural Science Foundation of China (NSFC, Project No

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