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Especially, CPN could be easily oxidized, resulting in the loss of its intrinsic chemical inertness and its surface corrodibility for further dissolution in weakly acidic organelles, such as endosomes and lysosomes, to release toxic Pt ions for DNA cross-linking (Figure 12B)

After 96 h, wells were aspirated, washed with PBS, and a fixative/staining solution containing 3.7% formaldehyde (Fisher Scientific, F75P-1GAL) and 5 g ml 1 Hoechst 33342, trihydrochloride, trihydrate (Invitrogen, H1399) was added

Abstract There is a critical need for new mechanism-of-action drugs that reduce the burden of obesity and associated chronic metabolic comorbidities

Interestingly, Tian et al

This distinction raises the possibility that declining renal GPX4 content and increasing urine GPX4 levels may represent different facets of the same pathological process, namely that GPX4 depletion from tubular cells is accompanied by its leakage or shedding into urine during oxidative or ferroptotic injury