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It is the most prevalent connexin found in the CNS, primarily located in astrocytes, and it exists as gap junctions and hemichannels, facilitating both intercellular and intracellular communication (Zhan et al., 2023)

Additionally, McConkey et al., in 1967, observed the occurrence of transparent skin that was associated with a decrease in dermal collagen in postmenopausal women [21]

Some ITCs demonstrate a hormetic effect, offering cytoprotective benefits at low doses and cytotoxic, antitumor properties at higher doses (149, 150)

These T cells may release perforin and granzyme, leading to necrosis, apoptosis, or electrical silencing of the respective neurons

OC36 Schileo E